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Explosive Nitric Oxide & Carnosine Support

Posted in: Fitness Performance  on Thursday, September 18, 2008
Max Muscle Sports Nutrition (MMSN) is pleased to introduce its newest innovation Max Nitro EXT. A scientifically and evidence-based formula designed to support the bodies production of nitric oxide and carnosine for explosive energy, muscle pump, and intensity.

Max Nitro EXT is a truly unique formula and a hybrid of two comprehensive blends. The MMSN Nitric Oxide Support Blend is composed of powerful ingredients to support the production of nitric oxide (NO). Nitric Oxide is formed by the action of the enzyme NO synthase (NOS) on the substrate L-arginine. There are 3 forms of NOS; inducible NOS (iNOS), endothelial NOS (eNOS) and neural NOS (nNOS).

The eNOS, found in the vascular endothelium, is most important for athletic performance. This Blend contains the exciting ingredient GlycoCarn®  USP (Glycine Propionyl-L-Carnitine HCI); Sigma-tau HealthScience, Inc.(Patent#6,703,042) which is an advanced ester of L-carnitine. GlycoCarn® is  proven to increase plasma NO and promoting maximum muscular energetics for enhanced training intensity. GlycoCarn® is also a powerful antioxidant providing  protection against free radical which may damage muscle and other cells. Other  science-supported ingredients to increase NO production in the Blen include  arginine alpha-ketoglutarate (A-AKG), L-norvaline, N-acetyl cysteine (NAC),  alpha lipoic acid (ALA), icariin (Epimedium sagittatum), gypenoside (Gynostemma  pentaphyllum), and pine bark extract (proanthocyanins). NO synthase is a very  complex enzyme requiring the cofactors riboflavin and thiamin. These two  essential vitamins have been added to support optimal enzyme function along with  magnesium and vitamin C. Magnesium is a component of hundreds of enzymes  involved in metabolism and energy support. Vitamin C serves as a intracellular
stimulator of NO production along with powerful antioxidant functions.

The MMSN Carnosine Support Blend contains beta-alanine and L-histidine. Both amino acids make up carnosine found in the muscles. Muscle carnosine increses the buffering capacity in muscles as a result of the accumulation of hydrogen (H+) ions released from lactic acid (lactate)  during high intensity exercise. Carnosine levels are generally higher in muscles  and concentrated primarliy in the "fast-twitch" (Type II) fibers. Studies have  also shown that carnosine enhances the antioxidative effect of Vitamin E.

Additionally, carnosine may also support NO production. The Blend also includes  L-citrulline malate shown to promote aerobic energy production and serves to  remove lactate and ammonia from muscle cells to reduce muscle fatigue. L-Taurine  is a non-essential sulfur containing amino acid with high concentrations found  in skeletal muscles and appears to play a role in cellular defenses (cytroprotective).

L-Taurine is often depleted during extreme physical exertion and has been shown  to prolong fatigue.

Size: 410 Grams
Serving Size: 13.7 Grams
Servings Per Container: 30

Delays the Onset of Muscle Fatigue
Promotes Improved Anaerobic Performance
Optimizes Energy Production and Blood Flow
Enhanced Power, Speed and Intensity
Enhanced Muscle Recovery

Unique hybrid of two comprehensive blends to promote explosive NO production and improved anaerobic performance.

The MMSN Nitric Oxide Support Blend  contains GlycoCarn® USP (Glycine Propionyl-L-Carnitine HCI); Sigma-tau health Science, Inc. (Patent #6,703,042) a proven to increase plasma NO and  promote maximum muscular energetics for enhanced training intensity. GlycoCarn®  is also a powerful antioxidant protecting muscle cells against free radicals which may be produced during exercise.

Enhanced NO production by providing arginine-alphaketoglutarate (A-AKG), L-norvaline, N-acetylcysteine (NAC), alpha lipoic acid (ALA), icariin (Epimedium sagittatum), gypenoside (Gynostemma  pentaphyllum), and pine bark extract (proanthocyanins) and vitamin C.

The MMSN Carnosine Support Blend contains the two amino acids that make up carnosine, beta-alanine and histidine.

Increasing carnosine promotes the intracellular buffering capacity within
muscles of hydrogen ions (H+) generated from lactic acid (lactate) during
high-intensity exercise this increasing the lactate or anaerobic threshold.

Enhances high-intensity exercise  performance, powerful antioxidant and the delay of fatigue with the addition  of L-taurine.

Contains L-citrulline malate which promotes  aerobic energy production, functions to remove lactic acid and ammonia from  muscles, reduces muscle fatigue and supports the synthesis of arginine for  superior nitric oxide (NO) production.

Contains a  unique buffered form of magnesium chelate along with vitamin C as an intracellular antioxidant.

Riboflavin and niacin have been added to  support optimal NO synthase (NOS) function.

Key References:
1. Heller R. Munscher-Paulig F, Grabner R, Till U. L-ascorbic  acid potentiates nitric oxide synthesis in endothelial cells. J Biol Chem  1999;274(12):8254-60

2. Zou MH, Shi C, Cohen RA. Oxidation of the zinc-thiolate  complex and uncoupling of endothelial nitric oxide synthase by peroxynitrate.  J Clin Invest. 2002;109:817-826

3. Alexander E, Black PM, Cooke JP. L-arginine normalizes  endothelial function in cerebral vessels from hypercholesterolemic rabbits. J  Clin Invest. 1991;87:1295-1295

4. Brocato L, Martina V, Masha A et Al. Long Term N-acetylcysteine  and L-arginine administration reduces endothelial activation and systolic  blood pressure in hypertensive patients with type 2 diabetes mellitus.  Diabetes Care. 2008;[Epub ahead of print].

5. Agar A, Akpinar D, Derin N et al. The effect of the lipoic  acid on antioxidant status and lipid peroxidation in rats exposed to chronic  restraint stress. Physiol Res. 2007; [Epub ahead of print].

6. Huang ZQ, Xu HB. Icariin enhances endothelial nitric-oxide  synthase expression on human endothelial cells in vitro. Vascular  Pharmacology. 2007;47:18-24.

7. Bu X, Myers PR, Steimle A et al. The direct release of  nitric oxide by gypenosides derived from the herb Gynostemma pentaphyllum.  Nitric Oxide. 1999;3:359-365

8. Derave W, Ozdemir MS, Harris RC et al. Beta-alanine  supplementation augments muscle carnosine content and attenuates fatigue  during repeated isokinetic contraction bouts in trained sprinters. J Appl  Physiol. 2007;103:1736-43

9. Babizhayev MA, Seguin MC, Gueyne J et al. L-carnosine  (beta-alanyl-L-histidine) and carcinine act as a natural antioxidants with  hydroxyl-radical scavenging and lipid-peroxidase activites. Biochem J.  1994;304:509-516.

10. Bendahan D, Mattei JP, Ghattas B et al. Citrulline/malate  promotes aerobic energy production in human exercising muscle. Br J Sports  Med. 2002;36:282-289

11. Ratamess NA, Hoffman JR, Ross R et al. Effects of an amino  acid/creatine energy supplement on the acute hormonal response to resistance  exercise. Int J Sport Nutr Exerc Metab. 2007;17:608-623.

12. Bachetti T, Comini L, Franolini G et al. Arginase pathway  in human endothelial cells in pathophysiological conditions. J Mol Cell  Cardiol. 2004;37:515-523